Cardinals vs 49ers Prediction and Preview - NFL Week 18, 2025
Last updated: Jan 5, 2025, 9:20PM | Published: Dec 31, 2024, 8:30AM
The Arizona Cardinals will face the San Francisco 49ers in NFL Week 18 action at State Farm Stadium on Monday, beginning at 8:25am AEDT.
This article features Stats Insider's prediction and tips for the Cardinals vs 49ers game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of Monday's Arizona vs San Francisco NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Cardinals a 67% chance of defeating the 49ers in Week 18 of the NFL season.
Cardinals vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at State Farm Stadium are listed here:
- Head to Head: Cardinals $1.42, 49ers $2.95
- Line: Cardinals -5 ($1.91), 49ers +5 ($1.91)
- Total (Over/Under 43 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $1.42 and the 49ers at $2.95.
The Cardinals are 5-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+5) are predicted to cover the line 52% of the time, while the 43-point over/under is expected to stay under 52% of the time.
Cardinals vs 49ers: Betting Tips
- Head to Head: San Francisco at $2.95 with Bet365
- Line: 49ers +5 at $1.91 with Bet365
- Total Points: Under 43 at $1.91 with Bet365
While the Cardinals have a higher chance of winning the game, betting on the 49ers to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Making use of the edges published here at Stats Insider is pivotal to being profitable in the long run.
Cardinals vs 49ers: Prediction
Stats Insider's predicted final score for Cardinals vs 49ers at State Farm Stadium in Week 18 is the Cardinals winning 23-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs San Francisco game in Week 18, including data-driven predictions and expert tips.
For in-depth analysis from US experts,, check out Dimers' detailed Cardinals vs 49ers prediction.
Cardinals vs 49ers: TD Scorer Tips
Who will score an anytime touchdown in Cardinals vs 49ers? The latest data is in.
According to Stats Insider, Arizona's Michael Carter is the most likely player to score the first TD in Cardinals vs 49ers.
Carter has a 12.0% chance of scoring the first TD at State Farm Stadium, while the Cardinals RB has a 45.8% chance of registering an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Cardinals First TD Tips
- Michael Carter: 12.0% probability
- Trey McBride: 10.5% probability
- Kyler Murray: 9.8% probability
- Marvin Harrison: 9.3% probability
- Michael Wilson: 4.6% probability
49ers First TD Tips
- Isaac Guerendo: 11.6% probability
- Jauan Jennings: 9.2% probability
- George Kittle: 8.7% probability
- Ricky Pearsall: 5.9% probability
- Joshua Dobbs: 5.2% probability
Anytime Touchdown Scorer Tips
Cardinals Anytime TD Tips
- Michael Carter: 45.8% probability
- Trey McBride: 42.1% probability
- Kyler Murray: 39.7% probability
- Marvin Harrison: 39.0% probability
- Michael Wilson: 21.1% probability
49ers Anytime TD Tips
- Isaac Guerendo: 45.9% probability
- George Kittle: 37.5% probability
- Jauan Jennings: 37.1% probability
- Ricky Pearsall: 25.7% probability
- Joshua Dobbs: 22.5% probability
Cardinals-49ers Projected Player Stats
Of the starting quarterbacks, the Cardinals' Kyler Murray is projected for 217 passing yards, while the 49ers' Joshua Dobbs is expected to throw for 200 yards.
Cardinals Starting QB
- Kyler Murray: 217 projected passing yards
49ers Starting QB
- Joshua Dobbs: 200 projected passing yards
Cardinals Rushing Yards
- Michael Carter: 62 projected yards
- Kyler Murray: 43 projected yards
- DeeJay Dallas: 17 projected yards
49ers Rushing Yards
- Isaac Guerendo: 79 projected yards
- Joshua Dobbs: 34 projected yards
- Patrick Taylor: 10 projected yards
Cardinals Receiving Yards
- Trey McBride: 72 projected yards
- Marvin Harrison: 54 projected yards
- Michael Wilson: 33 projected yards
- Michael Carter: 20 projected yards
- Elijah Higgins: 18 projected yards
49ers Receiving Yards
- Jauan Jennings: 67 projected yards
- George Kittle: 56 projected yards
- Ricky Pearsall: 40 projected yards
- Isaac Guerendo: 16 projected yards
- Kyle Juszczyk: 11 projected yards
Our model updates frequently, so bookmark this page for the latest betting tips before the Arizona vs San Francisco match-up.
As always, see Stats Insider's Best Bets to get betting tips on every NFL game, plus predictions for a wide range of other sports.
Cardinals vs 49ers: Week 18 Essential Details
The NFL Week 18 match-up between the Cardinals and 49ers at State Farm Stadium is scheduled to start at 8:25am AEDT on Monday.
- Teams: Arizona Cardinals vs San Francisco 49ers
- Date: Monday 6 January 2025
- Time: 8:25am AEDT
- Venue: State Farm Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Arizona vs San Francisco predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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