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Cubs vs Diamondbacks Prediction and MLB Tips - 21 April 2025

The Chicago Cubs will face the Arizona Diamondbacks in MLB action at Wrigley Field on Monday, commencing at 4:20am AEST.

Jameson Taillon (1-1, 5.40 ERA) will be on the bump for the Cubs, up against Merrill Kelly (3-1, 5.57 ERA) for the Diamondbacks.

This article features Stats Insider's prediction and tips for the Cubs vs Diamondbacks game, along with the latest betting odds in Australia.

Who Will Win?

Using trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Cubs vs Arizona MLB match-up 10,000 times.

Our leading predictive analytics model currently gives the Cubs a 53% chance of beating the Diamondbacks at Wrigley Field.

Cubs vs Diamondbacks: Odds

The latest betting odds in Australia for Monday's MLB game at Wrigley Field are listed here:

  • Head to Head: Cubs $1.77, Diamondbacks $2.10
  • Line: Cubs -1.5 ($2.75), Diamondbacks +1.5 ($1.47)
  • Total (Over/Under 7.2 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.77 and the Diamondbacks at $2.10.

The Cubs are listed as 1.5-run favourites against the Diamondbacks, with odds of $2.75 available at TAB.

For the underdog Diamondbacks (+1.5) to cover the line, TAB offers odds of $1.47.

The over/under for total runs scored is set at 7.2 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Diamondbacks (+1.5) are predicted to cover the line 66% of the time, while the 7.2-run over/under is expected to go over 54% of the time.

Cubs vs Diamondbacks: Betting Tips

  • Head to Head: Arizona at $2.10 with TAB
  • Line: Diamondbacks +1.5 at $1.47 with TAB
  • Total Runs: Over 7.2 at $1.91 with TAB

Our Cubs vs Diamondbacks predictions are based on complex modelling and gambling intelligence to help you place better bets with your chosen online bookie.

While the Cubs have a higher chance of winning the game, betting on the Diamondbacks to win is our preferred option due to the 1.0% edge found when comparing our data-driven probabilities to the odds currently available.

Making use of the edges seen on Stats Insider is one of the keys to achieving long-term success as a sports bettor.

Cubs vs Diamondbacks: Prediction

Stats Insider provides full coverage of the Cubs vs Arizona game on Monday, including data-driven predictions and expert tips.

Our model updates regularly, so bookmark this page for the latest betting analysis before the Cubs vs Arizona match-up.

As always, see Stats Insider's Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.

Cubs vs Diamondbacks: Essential Details

The match-up between the Cubs and Diamondbacks at Wrigley Field is scheduled to start at 4:20am AEST on Monday.

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Cubs vs Arizona predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.

If you decide to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures probabilities for the MLB.

Stats Insider

Stats Insider, Australia's leading predictive analytics website, offers Australian sports fans innovative tools and content to enhance their enjoyment of major sporting events both domestically and internationally. Our goal is to transform the sports fan experience by providing readily accessible, data-driven content for sports enthusiasts like us.

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