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Padres vs Cubs Prediction and MLB Tips - 16 April 2025

The San Diego Padres will take on the Chicago Cubs in MLB action at PETCO Park on Wednesday, starting at 11:40am AEST.

Randy Vásquez (1-1, 1.72 ERA) will get the ball for the Padres, while the Cubs will counter with Shota Imanaga (2-1, 2.70 ERA).

This article features Stats Insider's top betting tips for the Padres vs Cubs game, as well as the latest betting odds in Australia.

Who Will Win?

Utilising trusted computer power and data, Stats Insider has simulated the result of Wednesday's San Diego vs Cubs MLB match-up 10,000 times.

Our proven predictive analytics model currently gives the Cubs a 55% chance of beating the Padres at PETCO Park.

Padres vs Cubs: Odds

The latest betting odds in Australia for Wednesday's MLB game at PETCO Park are listed below:

  • Head to Head: Padres $2.30, Cubs $1.65
  • Line: Padres +1.5 ($1.74), Cubs -1.5 ($2.14)
  • Total (Over/Under 8 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Padres at $2.30 and the Cubs at $1.65.

The Padres are listed as 1.5-run underdogs against the Cubs, with odds of $1.74 available at TAB.

For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.14.

The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Padres (+1.5) are predicted to cover the line 59% of the time, while the 8-run over/under is expected to stay under 52% of the time.

Padres vs Cubs: Betting Tips

  • Head to Head: San Diego at $2.30 with TAB
  • Line: Padres +1.5 at $1.74 with TAB
  • Total Runs: Under 8 at $1.91 with TAB

These Padres vs Cubs betting tips are based on world-class simulations and gambling experience to help you place better bets with your chosen online bookie.

While the Cubs have a higher chance of winning the game, betting on the Padres to win is our recommended option because of the 3.2% edge identified when comparing our data-led probabilities to the odds currently on offer.

Making use of the edges published on Stats Insider is one of the keys to achieving long-term profitability.

Padres vs Cubs: Prediction

Stats Insider provides full betting coverage of the San Diego vs Cubs game on Wednesday, including data-driven predictions and live win probabilitiestips.

Remember, our model updates regularly, so bookmark this page for the latest betting tips before the San Diego vs Cubs match-up.

As always, see Stats Insider's Best Bets for betting tips on every MLB game, as well as predictions for a wide range of other sports.

Padres vs Cubs: Essential Details

The match-up between the Padres and Cubs at PETCO Park is scheduled to begin at 11:40am AEST on Wednesday.

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our San Diego vs Cubs predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.

Stats Insider

Stats Insider, Australia's leading predictive analytics website, offers Australian sports fans innovative tools and content to enhance their enjoyment of major sporting events both domestically and internationally. Our goal is to transform the sports fan experience by providing readily accessible, data-driven content for sports enthusiasts like us.

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