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Panthers vs Cowboys Prediction and Tips - NRL Round 5, 2025

The Panthers will sqaure off with the Cowboys in NRL Round 5 action at Panthers Stadium on Friday, beginning at 6:00pm AEDT.

This article features Stats Insider's prediction and tips for the Panthers vs Cowboys game, plus the latest betting odds and try scorer tips.

Who Will Win?

Using advanced computer power and data, Stats Insider has simulated the result of Friday's Penrith vs North Queensland NRL match 10,000 times.

Our leading predictive analytics model gives the Panthers an 83% chance of defeating the Cowboys in Round 5 of the 2025 NRL season.

Panthers vs Cowboys: Odds

The latest Bet365 betting odds for Friday's NRL clash at Panthers Stadium are shown below:

  • Head to Head: Panthers $1.20, Cowboys $4.80
  • Line: Panthers -13.5 ($1.91), Cowboys +13.5 ($1.91)
  • Total (Over/Under 49.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $1.20 and the Cowboys at $4.80.

The Panthers are 13.5-point favourites against the Cowboys, with odds of $1.91 available at Bet365.

For the underdog Cowboys (+13.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Panthers (-13.5) are predicted to cover the line 53% of the time, while the 49.5-point over/under is expected to stay under 57% of the time.

Panthers vs Cowboys: Best Bets

  • Head to Head: Panthers at $1.20 with Bet365
  • Line: Panthers -13.5 at $1.91 with Bet365
  • Total Points: Under 49.5 at $1.91 with Bet365

When you see a 🔥, that means you've found one of Stats Insider's best bets for today across all sports.

Our Panthers vs Cowboys best bets are based on market-leading simulations and betting experience to give you the best possible advice 24/7.

Panthers vs Cowboys: Prediction

Stats Insider's predicted final score for Panthers vs Cowboys at Panthers Stadium on Friday is the Panthers winning 29-15.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the Panthers vs Cowboys match on Friday, including data-driven predictions and the best betting tips.

18+. Odds correct at time of publishing and subject to change.

Panthers vs Cowboys: Try Scorers

Looking for Panthers vs Cowboys try scorers? The latest data is in.

According to Stats Insider, the Panthers' Paul Alamoti is the most likely player to score the first try in Penrith vs North Queensland.

Alamoti has a 9.4% chance of scoring the first try at Panthers Stadium, while the Panthers star has a 52.0% chance of scoring a try at any time during the match.

Scroll down for our full list of first try scorer and anytime try scorer probabilities.

First Try Scorer Tips

Penrith Panthers

  • Paul Alamoti: 9.4% probability
  • Casey McLean: 9.2% probability
  • Izack Tago: 6.8% probability
  • Luke Garner: 6.4% probability
  • Nathan Cleary: 5.8% probability

North Queensland Cowboys

  • Murray Taulagi: 5.2% probability
  • Robert Derby: 4.7% probability
  • Scott Drinkwater: 3.4% probability
  • Jaxon Purdue: 3.3% probability
  • Tom Dearden: 3.0% probability

Anytime Try Scorer Tips

Penrith Panthers

  • Casey McLean: 52.3% probability
  • Paul Alamoti: 52.0% probability
  • Izack Tago: 43.5% probability
  • Luke Garner: 42.2% probability
  • Thomas Jenkins: 39.4% probability

North Queensland Cowboys

  • Murray Taulagi: 35.5% probability
  • Robert Derby: 32.1% probability
  • Scott Drinkwater: 28.1% probability
  • Jaxon Purdue: 26.4% probability
  • Tom Dearden: 22.8% probability

Remember, our model updates regularly, so keep checking this article for the latest betting predictions before the Panthers vs Cowboys match.

As always, see our Best Bets to get betting tips on every NRL match, as well as predictions for a wide range of other sports.

Panthers vs Cowboys: Essential Details

The NRL Round 5 clash between the Panthers and Cowboys at Panthers Stadium is scheduled to commence at 6:00pm AEDT on Friday.

All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.

Conclusion

Our Panthers vs Cowboys predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our rugby league tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

If you purchase a product or register for an account through one of the links on our site, we may receive compensation.

More on the NRL

Stats Insider is your home for betting on the NRL, with the latest NRL betting news, tips for every NRL game, and futures probabilities for the NRL.

Stats Insider

Stats Insider, Australia's leading predictive analytics website, offers Australian sports fans innovative tools and content to enhance their enjoyment of major sporting events both domestically and internationally. Our goal is to transform the sports fan experience by providing readily accessible, data-driven content for sports enthusiasts like us.

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